diff --git a/packages/devtools_app/lib/src/extensions/embedded/_controller_web.dart b/packages/devtools_app/lib/src/extensions/embedded/_controller_web.dart
index ab96f867ec0..247d3c6a4dd 100644
--- a/packages/devtools_app/lib/src/extensions/embedded/_controller_web.dart
+++ b/packages/devtools_app/lib/src/extensions/embedded/_controller_web.dart
@@ -59,6 +59,14 @@ String _debugExtensionPlaceholderHtml(String name) {
 ''';
 }
 
+/// The sandbox permissions granted to embedded extension iframes.
+///
+/// Grants the extension same-origin capabilities (needed for service workers,
+/// storage, etc.) while allowing javascript execution, forms, downloads, and
+/// popup windows.
+const _extensionSandboxRules =
+    'allow-scripts allow-same-origin allow-forms allow-downloads allow-popups allow-popups-to-escape-sandbox';
+
 class EmbeddedExtensionControllerImpl extends EmbeddedExtensionController
     with AutoDisposeControllerMixin {
   EmbeddedExtensionControllerImpl(super.extensionConfig);
@@ -123,7 +131,8 @@ class EmbeddedExtensionControllerImpl extends EmbeddedExtensionController
       // This url is safe because we built it ourselves and it does not include
       // any user input.
       ..src = extensionUrl
-      ..allow = 'usb';
+      ..allow = 'usb'
+      ..sandbox.value = _extensionSandboxRules;
     _extensionIFrame.style
       ..border = 'none'
       ..height = '100%'
diff --git a/packages/devtools_app/release_notes/NEXT_RELEASE_NOTES.md b/packages/devtools_app/release_notes/NEXT_RELEASE_NOTES.md
index 0d7aeb830ce..21e70e2bbcc 100644
--- a/packages/devtools_app/release_notes/NEXT_RELEASE_NOTES.md
+++ b/packages/devtools_app/release_notes/NEXT_RELEASE_NOTES.md
@@ -79,6 +79,8 @@ TODO: Remove this section if there are not any updates.
 
 * Hide the DevTools extensions menu button in single-screen embedded mode (`EmbedMode.embedOne`) on standard screens.
   [#8507](https://github.com/flutter/devtools/issues/8507)
+* Added iframe sandboxing for embedded DevTools extensions to enforce origin
+  isolation. [#9967](https://github.com/flutter/devtools/pull/9967)
 
 ## Advanced developer mode updates